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And genomic technology of multiple framework integrated for Cancer Research An AbstractThe rapid development of OMIC technology, in order to apply the technology of multiple genome, cancer researchers will be easier at the same time. Indeed, the complex nature of cancer biology, which is why that need tools for data integration us. Given the complexity of managing the format of the data set and multiple technologies, several projects, including the (BRIDG) biomedical laboratory and domain groups applicability limited cancer biomedical informatics grid and (caGRID) have been introduced. We, the data model of canada goose men hybridge lite object-oriented, introduce Web-based applications with a caged OM using Xperanto cage for Cancer Genomics Object Model (cage OM), a hybrid object-relational mapping technology with the genomic data of multiple You. Hybrid system is using a objectrelational mapping has been extended to include the dynamic structure using entity attribute value (EAV) model. Xperanto cage and cage the OM, in an attempt to establish a comprehensive framework for the interpretation of genome data and multiple clinical and integrated storage, to facilitate the integration of model-level data types other emerging some. Pilot implementation for tissue diseases Genome Information Systems clinical and pathological integrated is introduced. Simultaneously quest for measuring the multi-portion of the biological system is generating the data heterologous genomes, a huge amount appearance of BackgroundThe various high new mens canada goose throughput technologies [1 (proteins, such as metabolites, and mRNA) ]. And a MAGE OM, for expressing manages Academic genomics data, specific data model of several techniques, transcript suggested [2], Pedro proteomics canada goose parka jassen [3], SMAR [4], ArMET [ and for MIAMET [6] metabolomics for tissue microarray, and 5], tissue microarray object model (OM TMA) [7]. Data models using genomic techniques plurality, despite the increase in the number of cancer research, integrated for clinical data and functional genomics plurality experimental absent. Early efforts of some, have been introduced in order to solve this problem. Applications (BRIDG) provides biomedical Canada Goose Outlet Online laboratory domain group the National Cancer Institute (NCI) cancer Biomedical Informatics Grid and (caGRID) is, architecture and large-scale between modules not completed yet fully, the purpose that it is prohibitively expensive in practice is limited may interdependency issues some applications worldwide [8,9]. Effects on the chemical and biological systems (CEBS) include cancer genomics data, but it is not focused on functional genomics data domain in toxicity [10]. If you represent the data from multiple omics technologies has proposed clinical cancer genomics Object Model (cage OM) histopathological cancer research domain [11] with TMA OM we, [7]. In this study, in an attempt to establish a comprehensive framework for the interpretation of the genome data type and multiple clinical and design flexible and comprehensive integrated storage, by using the object-relational mapping technology of hybrid, Web-based application, I have implemented Xperanto cage. TMA OM fugue OM, MAGE OM, and Pedro). In order to model the histopathological data and clinical, we analyze the management workflow of cancer, University of pathologists in the United States (CAP), cancer Protocol (CPS) National Cancer Institute (NCI ) common data Emement (CDE is) document referenced models of histopathological information and clinical such as [11]. Cage OM is a data model that includes (FIG. 1) 183 classes are grouped into packages 25. TechnologySpecificData namespace bio data general, and ClinicalData: Most packages will be sorted by name space of three. Packages of the remaining 6 are reused from MAGE OM packages associated. OM cage is expressed in a class diagram of Unified Modeling Language (UML) is a standard notation for representing visualization design and system architecture. Figure. One Relationship of package of cage OM 25. Most packages can be classified into three namespaces in this model. CommonBioData (yellow), TechnologySpecificData and (Pink) ClinicalData (blue). The (gray), package of six, has been adopted from MAGE OM. Database designThe relational database schema of Xperanto cage, derived from the cage OM by using the object-relational mapping technique of hybrid. The object mapping basic rule of three, there is a [12]. All attributes of all classes canada goose kensington parka 2xl in the hierarchy are stored: one table per class hierarchy whole. Each table, an attribute of a particular class, both of the attributes of any that inherit from it are included: one table for each concrete class. Including the abstract superclass, in one table, for each class: supports polymorphism, each attribute of the inheritance tree of the class is represented by a table only once. This rule, so hip space dose does not provide ad hoc reports efficient, the purpose of the second, chose relational mapping rules we. All the attributes of a single class of any has been stored in one table. We also, entity, apply the value (EAV) model attribute to canada goose outlet ca attribute the flexibility and heterogeneity To add a new attribute to the class to solve the problems associated with the storage of sparse attribute. In addition, EAV model called the modeling of the line, and stores the values ​​in the row attribute with the name of the attribute of another column. EAV model is implemented in the management system of the data set [14, 13] widely disparate. Detailed mapping process is as follows. Each table in the specific attributes of the class, with the exception of the abstract class it, both of the attributes of any inheritance is included. According to the multiple between the classes, the association, has been defined as one of the normal form. For example, one or more of (1) multiplicity is expressed as the normal form of the second in a relational database. Some of the classes sparse, belongs to ClinicalData namespace with attributes of different kinds, based on the EAV model, it is mapped on the table. Abstract class does not capture. Association of abstract class is passed to the subclass of. Development of a clinical pilot system: the purpose of the development of a pilot system for evaluating integrated in the clinical practice of actual BioEMRFor, the utility of clinical histopathological, high-throughput biological data, Xperanto cage BioEMR we Breast Cancer Center of Seoul National University Hospital, which has established a pilot information system named (Figure 2). Figure. Two BioEMR. Clinical integrated architecture of pilot information system of genomic information and the organization's disease pathology. Most of the clinical data, it can be expressed in XML-based standards, including HL 7, LOINC, the CDA and DICOM from the clinical information system of the related art. Biological data standard for data from genomics laboratory will contain the TMA OM BSML, MAGE ML, and MIAPE. Extract the XML file, which is also deposited in a layer integrated document repository for data processing. Integrated document repository, is analyzed by a set of analysis module and it is supported by the knowledge database of clinical trials and clinical research. Currently, in parallel with the legacy system in the primary real-time hospital, the secondary information system, the pilot application module using IDR. By integrating the external resourcesWe is using the MGED ontology for the array information and description of the general experimental procedure. In order to describe the clinical histopathological data and TMA canada goose women xxl Specifically, we use a controlled vocabulary defined in the OM of TMA [7]. Information and disease ontology, such as genomics and proteomics [16] is the annotation integrated database of genes involved grip.